Targeting Tumour Soil with Mechanical Forces

12 Dec 2025 under Highlights

Tumour progression is inherently influenced by its microenvironment (“tumour soil”) rather than the cancer cells themselves. A major component of this milieu are cells called cancer-associated fibroblasts (CAFs). CAFs orchestrate extracellular matrix remodeling, modulate tissue mechanics, and establish a permissive stromal (supportive tissue) niche that supports tumour proliferation, invasion, and therapeutic resistance. Despite their central […]

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