Tiny But Mighty: Unlocking Hidden Power of Transactivation Domains

16 Feb 2025 under Highlights

Researchers at the Department of Biochemistry, IISc, led by PN Rangarajan have discovered that tiny segments of a transcription factor (protein) containing just nine amino acids can independently activate genes in Komagataella phaffii (formerly Pichia pastoris), a yeast widely used in biotechnology. Their study, published in Journal of Biological Chemistry, challenges the belief that large, complex protein segments […]

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