Events During Cell Membrane Lysis by Toxins
07 Feb 2026 under Highlights
Staphylococcus aureus infections have become a global threat to human health due to the rapid emergence of multidrug-resistant strains. The limited availability of antibiotics and the absence of approved vaccines make it extremely challenging to combat S. aureus. To address this issue, it is crucial to study the pathophysiology of S. aureus. Alpha-hemolysin (α-HL), a pore-forming toxin (PFT), […]
How Bacterial Toxins Punch Holes in Membranes
26 Jul 2025 under Highlights
The rise of multi-drug-resistant Staphylococcus aureus has become a global health concern, with a toxin called alpha-haemolysin (α-HL) playing a central role in the bacterium’s pathogenesis. Despite extensive studies, most structural analyses of α-HL have been performed using detergents or one lipid moiety, which do not reflect the complexity of natural cell membranes. In a […]